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Article

Lithium drives coordinated changes in the mouse synaptic phosphoproteome

2026-04-21

Abstract excerpt

Lithium is the gold standard mood stabiliser used to treat cycling mania and depression in bipolar disorder. Despite seven decades of clinical use, the mechanisms of its mood stabilisation are incompletely understood, fundamentally limiting development of improved alternatives. Two established lithium targets, glycogen synthase kinase 3β (GSK3β) and inositol monophosphatase, both modulate phosphorylation, suggesti...

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Literature Corpus work
0049e76b-7550-5f4e-9490-0907ae0c660d
DOI
10.64898/2026.04.16.718903
Open publication

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Lithium drives coordinated changes in the mouse synaptic phosphoproteomeDOI 10.64898/2026.04.16.718903
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