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Article

Combined Tumor Suppressor Defects Characterize Clinically Defined Aggressive Variant Prostate Cancers.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2016

Aparicio Ana M, Shen Li, Tapia Elsa Li Ning, Lu Jing-Fang, Chen Hsiang-Chun, Zhang Jiexin, Wu Guanglin, Wang Xuemei, Troncoso Patricia, Corn Paul, Thompson Timothy C, Broom Bradley, Baggerly Keith, Maity Sankar N, Logothetis Christopher J

Abstract excerpt

PURPOSE: Morphologically heterogeneous prostate cancers that behave clinically like small-cell prostate cancers (SCPC) share their chemotherapy responsiveness. We asked whether these clinically defined, morphologically diverse, "aggressive variant prostate cancer (AVPC)" also share molecular features with SCPC. EXPERIMENTAL DESIGN: Fifty-nine prostate cancer samples from 40 clinical trial participants meeting...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26546618
DOI: 10.1158/1078-0432.CCR-15-1259
PMCID: PMC4794379

Genes

PTEN
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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