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Article

Comprehensive serial molecular profiling of an "N of 1" exceptional non-responder with metastatic prostate cancer progressing to small cell carcinoma on treatment.

Journal of hematology & oncology - 6 Oct 2015

Kadakia Kunal C, Tomlins Scott A, Sanghvi Saagar K, Cani Andi K, Omata Kei, Hovelson Daniel H, Liu Chia-Jen, Cooney Kathleen A

Abstract excerpt

IMPORTANCE: Small cell carcinoma/neuroendocrine prostate cancer (NePC) is a lethal, poorly understood prostate cancer (PCa) subtype. Controversy exists about the origin of NePC in this setting. OBJECTIVE: To molecularly profile archived biopsy specimens from a case of early-onset PCa that rapidly progressed to NePC to identify drivers of the aggressive course and mechanisms of NePC origin and progression. DESIGN,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26444865
DOI: 10.1186/s13045-015-0204-7
PMCID: PMC4596504

Genes

MYCL
SMAD4
PTEN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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