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URI alleviates tyrosine kinase inhibitors-induced ferroptosis by reprogramming lipid metabolism in p53 wild-type liver cancers.

2023-01-11

Abstract excerpt

<title>Abstract</title> <p>Tyrosine kinase inhibitors (TKIs)-based systemic therapy for advanced hepatocellular carcinoma (HCC) has only limited clinical benefit and reaches a bottleneck due to its drug resistance. Here, through whole transcriptome sequencing (RNA-Seq) and lipidomic analysis, we uncover that lipid metabolism reprogramming mediated by unconventional prefoldin RPB5 interactor (URI) endows HCC with...

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Literature Corpus work
0d5c2cbb-714a-5a1f-806f-23172f94af85
DOI
10.21203/rs.3.rs-2341124/v1
Open publication

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URI alleviates tyrosine kinase inhibitors-induced ferroptosis by reprogramming lipid metabolism in p53 wild-type liver cancers.DOI 10.21203/rs.3.rs-2341124/v1
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