Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Liver-specific ablation of Krüppel-associated box-associated protein 1 in mice leads to male-predominant hepatosteatosis and development of liver adenoma.

Hepatology (Baltimore, Md.) - 1 Oct 2012

Bojkowska Karolina, Aloisio Fabio, Cassano Marco, Kapopoulou Adamandia, Santoni de Sio Francesca, Zangger Nadine, Offner Sandra, Cartoni Cristina, Thomas Charles, Quenneville Simon, Johnsson Kai, Trono Didier

Abstract excerpt

UNLABELLED: The liver is characterized by sexually dimorphic gene expression translating into sex-specific differences in lipid, drug, steroid hormone, and xenobiotic metabolism, with distinct responses of males and females to environmental challenges. Here, we investigated the role of the Krüppel-associated box (KRAB)-associated protein 1 (KAP1) epigenetic regulator in this process. Liver-specific KAP1 knockout...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoma
Share to Biopsy, Needle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

Share to Fatty Liver

Share to Liver Neoplasms

Share to Random Allocation

Share to Sex Factors

Share to Zinc Fingers

Source

Open in PubMed Open full text

Identifiers

PMID: 22684873
DOI: 10.1002/hep.25767
PMCID: PMC4894457

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Liver-specific ablation of Krüppel-associated box-associated protein 1 in mice leads to male-predominant hepatosteatosis and development of liver adenoma.PMID 22684873Read ↗

Unraveling the Epigenetic Basis of Liver Development, Regeneration and DiseaseSemantic proximity Read ↗

BAP1 modulates endoplasmic reticulum stress signaling and balances liver homeostasis and malignant progressionSemantic proximity Read ↗

Polyphenic trait promotes liver cancer in a model of epigenetic instability in mice.Semantic proximity Read ↗

Sex-specific KDM6A-HNF4A-CREBH network controls lipoprotein cholesterol metabolism and atherosclerosis via epigenetic reprograming of hepatocytesSemantic proximity Read ↗

Sex-biased genetic programs in liver metabolism and liver fibrosis are controlled by EZH1 and EZH2Semantic proximity Read ↗

Chronic Disruption of the Late Cholesterol Synthesis Leads to Female-Prevalent Liver CancerSemantic proximity Read ↗

Androgen-mediated Perturbation of the Hepatic Circadian System Through Epigenetic Modulation Promotes NAFLD in PCOS MiceSemantic proximity Read ↗

Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X ReceptorsSemantic proximity Read ↗

Plasticity of Epigenomic and Transcriptomic Aging Reveals Common Targets for Reprogramming by Environmental ExposuresSemantic proximity Read ↗

Hepatic HKDC1 Deletion Alleviates Western Diet-Induced MASH in MiceSemantic proximity Read ↗

Single Nucleus MultiOmics Links Novel Transcription Factor Motifs to Murine Hepatic Sex Differences in Chromatin Accessibility and Metabolic Dysfunction-Associated Steatotic Liver DiseaseSemantic proximity Read ↗

NEAT1 accelerates the progression of liver fibrosis via regulation of microRNA-122 and Kruppel-like factor 6Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.