BAP1 inhibits the ER stress gene regulatory network and modulates metabolic stress response

Abstract excerpt

Significance BRCA1 associated protein 1 (BAP1) is a tumor suppressor and its inactivating mutations frequently occur in a subset of human cancers. This study reveals an unexpected finding that loss of BAP1 compromises the cellular adaptability to metabolic stress, and links BAP1 to unfolded protein response to regulate cell survival under metabolic stress. We also report the first line of in vivo evidence that...

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