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Article

Antibody-directed evolution reveals a mechanism for enhanced neutralization at the HIV-1 fusion peptide site

21 Nov 2023

Abstract excerpt

The HIV-1 fusion peptide (FP) represents a promising vaccine target, but global FP sequence diversity among circulating strains has limited anti-FP antibodies to ~60% neutralization breadth. Here we evolve the FP-targeting antibody VRC34.01 in vitro to enhance FP-neutralization using site saturation mutagenesis and yeast display. Successive rounds of directed evolution by iterative selection of antibodies for...

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PMID: 37989731
DOI: 10.1038/s41467-023-42098-5

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