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Morphological and Functional Characterization and Assessment of iPSC-Derived Hepatocytes for<i>In Vitro</i>Toxicity Testing

18 Jun 2015

Abstract excerpt

Drug-induced liver injury (DILI) remains a great challenge and a major concern during late-stage drug development. Induced pluripotent stem cells (iPSC) represent an exciting alternative in vitro model system to explore the role of genetic diversity in DILI, especially when derived from patients who have experienced drug-induced hepatotoxicity. The development and validation of the iPSC-derived hepatocytes as an...

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PMID: 26092927
DOI: 10.1093/toxsci/kfv117

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