Article

Liver-Chip: Reproducing Human and Cross-Species Toxicities

2019-05-15

Abstract excerpt

Nonclinical rodent and non-rodent toxicity models used to support clinical trials of candidate drugs may produce discordant results or fail to predict complications in humans contributing to drug failures in the clinic. Here we applied microengineered Organ-on-Chip (Organ-Chip) technology to design rat, dog, and human Liver-Chips containing species-specific primary hepatocytes interfaced with liver sinusoidal endo...

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Literature Corpus work: bad8d84a-8840-5410-9b79-9a7f8d4ab224
DOI: 10.1101/631002

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