Article

A hollow fiber membrane-based liver organoid-on-a-chip model for examining drug metabolism and transport

2024-08-15

Abstract excerpt

Liver-on-a-chip models predictive for both metabolism as well as canalicular and blood transport of drug candidates in humans are lacking. Here, we established an advanced, bioengineered and animal component-free hepatocyte-like millifluidic system based on 3D hollow fiber membranes (HFMs), recombinant human laminin 332 coating and adult human stem cell-derived organoids. Organoid fragments formed polarized and ti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 66ecc147-2980-5821-82b2-0019d297c54a
DOI: 10.1101/2024.08.12.607504

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A hollow fiber membrane-based liver organoid-on-a-chip model for examining drug metabolism and transportDOI 10.1101/2024.08.12.607504Read

A High-Throughput Microphysiological Liver Chip System to Model Direct and Idiosyncratic Drug-Induced Liver Injury Using Human Liver OrganoidsSemantic proximity Read

Comparison of hiPSC-derived hepatic organoids and liver-on-a-chip systems reveal microenvironment-driven maturationSemantic proximity Read

Evolution of Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates.Semantic proximity Read

Novel hepatocyte-like liver organoids recapitulate crucial mature hepatic functionsSemantic proximity Read

Enhanced Maturity and Functionality of Vascularized Human Liver Organoids through 3D Bioprinting and Pillar Plate CultureSemantic proximity Read

A pumpless body-on-a-chip model using a primary culture of human intestinal cells and a 3D culture of liver cellsSemantic proximity Read

High-Fidelity Drug-Induced Liver Injury Screen Using Human Pluripotent Stem Cell–Derived OrganoidsSemantic proximity Read

Liver-Chip: Reproducing Human and Cross-Species ToxicitiesSemantic proximity Read

Scalable production of tissue-like vascularized liver organoids from human PSCsSemantic proximity Read

Reproducible generation of human liver organoids (HLOs) on a pillar plate platform <i>via</i> microarray 3D bioprintingSemantic proximity Read

Current Perspective: 3D Spheroid Models Utilizing Human-Based Cells for Investigating Metabolism-Dependent Drug-Induced Liver InjurySemantic proximity Read

Enhancing the functional maturity of induced pluripotent stem cell–derived human hepatocytes by controlled presentation of cell–cell interactions in vitroSemantic proximity Read