Article

Comparison of hiPSC-derived hepatic organoids and liver-on-a-chip systems reveal microenvironment-driven maturation

2026-07-29

Abstract excerpt

Human liver organoids (HLOs) and liver-on-a-chip (LoC) systems are emerging as physiologically relevant human models for studying liver function, disease, and drug metabolism, often in combination with human induced pluripotent stem cell (hiPSC)-derived tissues. However, hiPSC-derived models often display batch-to-batch variation and incomplete maturation, and the contribution of microfluidic flow to hepatic matur...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9dc2db12-2033-5cb9-9a84-75d054aea691
DOI: 10.64898/2026.07.28.741157

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Comparison of hiPSC-derived hepatic organoids and liver-on-a-chip systems reveal microenvironment-driven maturationDOI 10.64898/2026.07.28.741157Read

A High-Throughput Microphysiological Liver Chip System to Model Direct and Idiosyncratic Drug-Induced Liver Injury Using Human Liver OrganoidsSemantic proximity Read

Multi‐omics analysis of hiPSCs‐derived HLCs matured on‐chip revealed patterns typical of liver regenerationSemantic proximity Read

A MICROFLUIDIC DEVICE FOR LONG-TERM MAINTENANCE OF ORGANOTYPIC LIVER CULTURESSemantic proximity Read

Scalable production of tissue-like vascularized liver organoids from human PSCsSemantic proximity Read

Enhanced Maturity and Functionality of Vascularized Human Liver Organoids through 3D Bioprinting and Pillar Plate CultureSemantic proximity Read

Improvements in Maturity and Stability of 3D iPSC-Derived Hepatocyte-like Cell CulturesSemantic proximity Read

A hollow fiber membrane-based liver organoid-on-a-chip model for examining drug metabolism and transportSemantic proximity Read

Regenerative human liver organoids (HLOs) in a pillar/perfusion plate for hepatotoxicity assaysSemantic proximity Read

Engineered Platforms for Maturing Pluripotent Stem Cell–Derived Liver Cells for Disease ModelingSemantic proximity Read

Towards an autologous iPSC-derived patient-on-a-chipSemantic proximity Read

Droplet-engineered organoids recapitulate parental tissue transcriptome with inter-organoid homogeneity and inter-tumor cell heterogeneitySemantic proximity Read

Scalable production of tissue-like vascularised liver organoids from human PSCsSemantic proximity Read