Article

PPARdelta signaling activation improves metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes

2021-07-12

Abstract excerpt

<h4>SUMMARY</h4> Pluripotent stem cell-derived cardiomyocytes (PSC-CMs) provide an unprecedented opportunity to study human heart development and disease. A major caveat however is that they remain functionally and structurally immature in culture, limiting their potential for disease modeling and regenerative approaches. Here, we address the question of how different metabolic pathways can be modulated in order...

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Literature Corpus work: 5b13ce98-d7ea-5dda-b361-4516ad3fff54
DOI: 10.1101/2021.07.12.451352

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