Article

The CNS Microenvironment Promotes Leukemia Cell Survival by Disrupting Tumor Suppression and Cell Cycle Regulation in Pediatric T-cell Acute Lymphoblastic Leukemia

2023-09-05

Abstract excerpt

<h4>ABSTRACT</h4> A major obstacle in improving survival in pediatric T-cell acute lymphoblastic leukemia is understanding how to predict and treat leukemia relapse in the CNS. Leukemia cells are capable of infiltrating and residing within the CNS, where they interact with the microenvironment and remain sheltered from systemic treatment. These cells can survive in the CNS niche, by hijacking the microenvironment...

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Literature Corpus work: 984f89c7-36a9-59f2-921a-a20805b97295
DOI: 10.1101/2023.09.01.555887

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