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Article

The Chromatin Regulator CHD8 Is a Context-Dependent Mediator of Cell Survival in Murine Hematopoietic Malignancies.

PloS one - 1 Jan 2015

Shingleton Jennifer R, Hemann Michael T

Abstract excerpt

Aberrant chromatin regulation is a frequent driver of leukemogenesis. Mutations in chromatin regulators often result in more stem-like cells that seed a bulk leukemic population. Inhibitors targeting these proteins represent an emerging class of therapeutics, and identifying further chromatin regulators that promote disease progression may result in additional drug targets. We identified the chromatin-modifying...

Read the complete abstract on PubMed

Topics

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Share to B-Lymphocytes
Share to Cell Death
Share to Chromatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fusion Proteins, bcr-abl

Share to Organ Specificity

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Receptor, Notch1

Share to RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 26588464
DOI: 10.1371/journal.pone.0143275
PMCID: PMC4654476

Genes

CHD8
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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