Article

Alternative Splicing of Tcfl5 Fine-tunes Notch1 Transcriptional Output and Cell Fate Decisions in T-cell Acute Lymphoblastic Leukemias

2025-10-08

Abstract excerpt

<title>Abstract</title> <p>Aberrant NOTCH1 signaling drives T-cell acute lymphoblastic leukemia (T-ALL). TCFL5 is highly expressed in T-ALL clinical samples, producing four isoforms with distinct expression patterns and risk associations. In leukemic cells, TCFL5 isoforms play opposing roles: the CHA isoform promotes proliferation, while TCFL5_E6 and TCFL5_E8 suppress tumor growth. Mechanistically, TCFL5 acts as...

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Literature Corpus work: 036ef441-6354-5946-a3aa-76f5e121d08c
DOI: 10.21203/rs.3.rs-7695228/v1

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