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Empagliflozin Improves Mitochondrial Biogenesis and Ameliorates Experimental Pulmonary Vascular Remodeling, But May Not Benefit Patients with Pulmonary Arterial Hypertension

2025-01-29

Abstract excerpt

<h4>Background</h4> The sodium glucose cotransporter 2 (SGLT2) inhibitor may improve mitochondrial biogenesis and attenuate pulmonary vascular remodeling in pulmonary arterial hypertension (PAH). We investigated the impact of empagliflozin in PAH. <h4>Methods</h4> Lung sections and primary cell cultures isolated from microvascular endothelial cells (MVECs) were collected from control subjects and PAH patients. MVE...

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Literature Corpus work: 5af8a088-3ac0-5f91-a176-112cb4c255a7
DOI: 10.1101/2025.01.27.25321226

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