Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondria as a primary determinant of angiogenic modality in pulmonary arterial hypertension.

The Journal of experimental medicine - 4 Nov 2024

Niihori Maki, James Joel, Varghese Mathews V, McClain Nolan, Lawal Odunayo Susan, Philip Rohit C, Baggett Brenda K, Goncharov Dmitry A, de Jesus Perez Vinicio, Goncharova Elena A, Rafikov Ruslan, Rafikova Olga

Abstract excerpt

Impaired pulmonary angiogenesis plays a pivotal role in the progression of pulmonary arterial hypertension (PAH) and patient mortality, yet the molecular mechanisms driving this process remain enigmatic. Our study uncovered a striking connection between mitochondrial dysfunction (MD), caused by a humanized mutation in the NFU1 gene, and severely disrupted pulmonary angiogenesis in adult lungs. Restoring the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endothelial Cells
Share to Familial Primary Pulmonary Hypertension

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypertension, Pulmonary

Share to Mitochondria

Share to Neovascularization, Pathologic

Share to Pulmonary Arterial Hypertension

Share to Pulmonary Artery

Source

Open in PubMed Open full text

Identifiers

PMID: 39320470
DOI: 10.1084/jem.20231568
PMCID: PMC11452743

Genes

PAH
NFU1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondria as a primary determinant of angiogenic modality in pulmonary arterial hypertension.PMID 39320470Read ↗

Mitochondria in Vascular Health and DiseaseSemantic proximity Read ↗

Single Mutation in the NFU1 Gene Metabolically Reprograms Pulmonary Artery Smooth Muscle Cells.Semantic proximity Read ↗

Updated perspective of EPAS1 and the role in pulmonary hypertensionSemantic proximity Read ↗

New insights into the pathology of pulmonary hypertension: implication of the miR-210/ISCU1/2/Fe-S axis.Semantic proximity Read ↗

The Interplay of Hypoxia Signaling on Mitochondrial Dysfunction and Inflammation in Cardiovascular Diseases and Cancer: From Molecular Mechanisms to Therapeutic ApproachesSemantic proximity Read ↗

BACH1 deficiency improves placental angiogenesis via SLC25A51-mediated mitochondrial NAD+ transport in intrahepatic cholestasis of pregnancySemantic proximity Read ↗

Pericytes contribute to pulmonary vascular remodeling via HIF2α signalingSemantic proximity Read ↗

Unraveling the role of HIF and epigenetic regulation in pulmonary arterial hypertension: implications for clinical research and its therapeutic approachSemantic proximity Read ↗

Liriodendrin Targets PFKFB3 to Suppress Inflammatory Phenotypic Transition and Vascular Remodeling in Pulmonary HypertensionSemantic proximity Read ↗

KLF6 activation marks an angiogenic and apoptosis resistant endothelial phenotype in pulmonary arterial hypertension.Semantic proximity Read ↗

Role of endothelial microRNA-150 in pulmonary arterial hypertensionSemantic proximity Read ↗

Angiogenesis and Pulmonary Hypertension: A Unique Process in a Unique DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.