Article

The hepcidin-ferroportin axis influences mitochondrial function, proliferation, and migration in pulmonary artery endothelial and smooth muscle cells

2023-10-09

Abstract excerpt

<h4>Rationale</h4> Elevated circulating hepcidin levels have been reported in patients with pulmonary artery hypertension (PAH). Hepcidin has been shown to promote proliferation of human pulmonary artery smooth muscle cells (PASMCs) in vitro, suggesting a potential role in PAH pathogenesis. However, the role of human pulmonary artery endothelial cells (PAECs) as either a source of hepcidin, or the effect of hepci...

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Literature Corpus work: 0c7318c7-78ba-527d-81df-2941cf03c1a7
DOI: 10.1101/2023.10.09.561497

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