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A Bayesian approach to estimate the probability of resistance to bedaquiline in the presence of a genomic variant

2022-08-30

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Bedaquiline is a core drug for treatment of rifampicin-resistant tuberculosis. Few genomic variants have been statistically associated with bedaquiline resistance. Alternative approaches for determining the genotypic-phenotypic association are needed to guide clinical care. <h4>Methods</h4> Using published phenotype data for variants in Rv0678, atpE, pepQ and Rv1979c gene...

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Literature Corpus work
5ac6068d-1027-5444-868b-83a12c6e4112
DOI
10.1101/2022.08.30.505812
Open publication

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A Bayesian approach to estimate the probability of resistance to bedaquiline in the presence of a genomic variantDOI 10.1101/2022.08.30.505812
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