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Predicting MmpR-based bedaquiline resistance using sequence- and structure-based features

2022-12-21

Abstract excerpt

Accurate molecular detection of resistance to bedaquiline, a core drug for the treatment of drug resistant tuberculosis, remains challenging. In this study, we investigated whether three sequence- and nine structure-based features describing the impact of Rv0678 variants on the MmpR transcriptional repressor could predict the bedaquiline phenotype of isolates containing Rv0678 variants. Paired genotypic and phen...

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Identifiers and source

Literature Corpus work
38e13b5d-87f0-5abe-ba12-b274c412bdc7
DOI
10.1101/2022.12.19.521152
Open publication

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Predicting MmpR-based bedaquiline resistance using sequence- and structure-based featuresDOI 10.1101/2022.12.19.521152
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