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The ciliary gene <i>INPP5E</i> confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic Hedgehog signalling

2021-06-06

Abstract excerpt

<h4>SUMMARY</h4> Defects in primary cilia, cellular antennas that controls multiple intracellular signalling pathways, underlie several neurodevelopmental disorders, but how cilia control essential steps in human brain formation remains elusive. Here, we show that cilia are present on the apical surface of radial glial cells in human foetal forebrain. Interfering with cilia signalling in human organoids by mutati...

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Literature Corpus work
8d9c2654-236d-51b2-b4e5-557b2a2ddab2
DOI
10.1101/2021.06.06.447245
Open publication

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