Article

Estrogen-related receptor alpha promotes thyroid tumor cell survival via a tumor subtype-specific regulation of target gene networks

2023-10-23

Abstract excerpt

<title>Abstract</title> <p>Mortalin (encoded by <italic>HSPA9</italic>) is a mitochondrial chaperone often overexpressed in cancer through as-yet-unknown mechanisms. By searching different RNA-sequencing datasets, we found that <italic>ESRRA</italic> is a transcription factor highly correlated with <italic>HSPA9</italic> in thyroid cancer, especially in follicular, but not C cell-originated, tumors. Consistent wi...

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Literature Corpus work: 5aaa4b1c-a8a3-515d-b199-4cc8b9b991bd
DOI: 10.21203/rs.3.rs-3463553/v1

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