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Article

FOXA1 Reprogramming Dictates Retinoid X Receptor Response in ESR1-Mutant Breast Cancer.

Molecular cancer research : MCR - 1 Jun 2023

Wu Yang, Li Zheqi, Wedn Abdalla M, Casey Allison N, Brown Daniel, Rao Shalini V, Omarjee Soleilmane, Hooda Jagmohan, Carroll Jason S, Gertz Jason, Atkinson Jennifer M, Lee Adrian V, Oesterreich Steffi

Abstract excerpt

Estrogen receptor alpha (ER/ESR1) mutations occur in 30% to 40% of endocrine resistant ER-positive (ER+) breast cancer. Forkhead box A1 (FOXA1) is a key pioneer factor mediating ER-chromatin interactions and endocrine response in ER+ breast cancer, but its role in ESR1-mutant breast cancer remains unclear. Our previous FOXA1 chromatin immunoprecipitation sequencing (ChIP-seq) identified a large portion of...

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Identifiers

PMID: 36930833
DOI: 10.1158/1541-7786.MCR-22-0516
PMCID: PMC10239325

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