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Article

Identification and functional characterization of nuclear mortalin in human carcinogenesis.

The Journal of biological chemistry - 5 Sept 2014

Ryu Jihoon, Kaul Zeenia, Yoon A-Rum, Liu Ye, Yaguchi Tomoko, Na Youjin, Ahn Hyo Min, Gao Ran, Choi Il-Kyu, Yun Chae-Ok, Kaul Sunil C, Wadhwa Renu

Abstract excerpt

The Hsp70 family protein mortalin is an essential chaperone that is frequently enriched in cancer cells and exists in various subcellular sites, including the mitochondrion, plasma membrane, endoplasmic reticulum, and cytosol. Although the molecular mechanisms underlying its multiple subcellular localizations are not yet clear, their functional significance has been revealed by several studies. In this study, we...

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Identifiers

PMID: 25012652
DOI: 10.1074/jbc.M114.565929
PMCID: PMC4155653

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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