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Thyroid Hormone Receptor Beta as Tumor Suppressor: Untapped Potential in Treatment and Diagnostics in Solid Tumors

2021-07-23

Abstract excerpt

There is compelling evidence that the nuclear receptor TRβ, a member of the thyroid hormone receptor (TR) family, is a tumor suppressor in thyroid, breast and other solid tumors. Cell-based and animal studies reveal that the liganded TRβ induces apoptosis, reduces an aggressive phenotype, decreases stem cell populations, and slows tumor growth through modulation of a complex interplay of transcriptional...

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Literature Corpus work
1ecaf969-0009-5fe2-bd99-62af086ac436
DOI
10.20944/preprints202107.0549.v1
Open publication

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Thyroid Hormone Receptor Beta as Tumor Suppressor: Untapped Potential in Treatment and Diagnostics in Solid TumorsDOI 10.20944/preprints202107.0549.v1
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