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Article

Cytokeratin-8 in Anaplastic Thyroid Carcinoma: More Than a Simple Structural Cytoskeletal Protein.

International journal of molecular sciences - 14 Feb 2018

Guo Dehuang, Xu Qinqin, Pabla Sarabjot, Koomen John, Biddinger Paul, Sharma Ashok, Pabla Simarjot, Pacholczyk Rafal, Chang Chien-Chung, Friedrich Kevin, Mohammed Kamran, Smallridge Robert C, Copland John A, She Jin-Xiong, Weinberger Paul M

Abstract excerpt

Anaplastic thyroid carcinoma (ATC) is almost universally fatal. Elevated keratin-8 (KRT8) protein expression is an established diagnostic cancer biomarker in several epithelial cancers (but not ATC). Several keratins, including KRT8, have been suggested to have a role in cell biology beyond that of structural cytoskeletal proteins. Here, we provide evidence that KRT8 plays a direct role in the growth of ATCs....

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Identifiers

PMID: 29443941
DOI: 10.3390/ijms19020577
PMCID: PMC5855799

Genes

KRT8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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