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Article

The Macroautophagy Machinery in MHC Restricted Antigen Presentation

25 Feb 2021

Abstract excerpt

Autophagy-related (ATG) gene products regulate macroautophagy, LC3-associated phagocytosis (LAP) and LC3-dependent extracellular vesicle loading and secretion (LDELS). These processes also influence antigen processing for presentation on major histocompatibility complex (MHC) molecules to T cells. Here, I summarize how these different pathways use the macroautophagy machinery, contribute to MHC class I and II...

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PMID: 33717153
DOI: 10.3389/fimmu.2021.628429

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