Article

Mitochondrial DNA Quantity and Relative Abundance of “Common Deletion” Mutation in Peripheral Nerve Tissues from Donors with HIV Sensory Neuropathy

2024-02-01

Abstract excerpt

<h4>Background: </h4> Distal sensory polyneuropathy (DSP) and distal neuropathic pain (DNP) remain significant challenges for older people with HIV (PWH), necessitating enhanced clinical attention. HIV and certain antiretroviral therapies (ART) can compromise mitochondrial function and impact mitochondrial DNA (mtDNA) replication, which is linked to DSP in ART-treated PWH. <h4>Methods:</h4> This study investigated...

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Literature Corpus work: 5a9d6cac-c093-54fe-8cf4-0e7f547ed18b
DOI: 10.20944/preprints202402.0060.v1

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