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Mitochondrial DNA Damage and Brain Aging in Human Immunodeficiency Virus

14 Jul 2020

Abstract excerpt

BACKGROUND: Neurocognitive impairment (NCI) remains common in people living with human immunodeficiency virus (PLWH), despite suppressive antiretroviral therapy (ART), but the reasons remain incompletely understood. Mitochondrial dysfunction is a hallmark of aging and of neurodegenerative diseases. We hypothesized that human immunodeficiency virus (HIV) or ART may lead to mitochondrial abnormalities in the brain,...

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PMID: 32722761
DOI: 10.1093/cid/ciaa984

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