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HIV Treatment and Associated Mitochondrial Pathology

25 Sept 2013

Abstract excerpt

Antiretroviral therapy has dramatically reduced mortality in human immunodeficiency virus (HIV) infection. In 1988, the suggestion that the first antiretroviral drug, zidovudine, was the potential cause of muscle pathology in HIV-infected persons resulted in structural and biochemical patient studies demonstrating acquired mitochondrial dysfunction. Assessment of subsequent nucleoside analog reverse transcriptase...

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PMID: 24067671
DOI: 10.1177/0192623313503519

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