Article
Large Mitochondrial DNA Deletions in HIV Sensory Neuropathy.
Neurology - 13 Jul 2021
Roda Ricardo H, Bargiela David, Chen Weiran, Perry Ken, Ellis Ronald J, Clifford David B, Bharti Ajay, Kallianpur Asha R, Oliveira Michelli F, Diaz Monica M, Rubin Leah H, Gavegnano Christina, McArthur Justin C, Hoke Ahmet, Polydefkis Michael
Abstract excerpt
OBJECTIVE: The primary objective of this study was to evaluate the correlation of large mitochondrial DNA (mtDNA) deletions in skin samples of people with HIV (PWH) with measures of neuropathy and prior exposure to therapy. We hypothesized that deletions would be associated with neuropathy. As secondary objectives, we determined the correlation of deletion burden with demographic data and neuropathy measures....
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