Article
Mitochondrial haplogroups and peripheral neuropathy during antiretroviral therapy: an adult AIDS clinical trials group study.
AIDS (London, England) - 2 Sept 2005
Hulgan Todd, Haas David W, Haines Jonathan L, Ritchie Marylyn D, Robbins Gregory K, Shafer Robert W, Clifford David B, Kallianpur Asha R, Summar Marshall, Canter Jeffrey A
Abstract excerpt
OBJECTIVE: HIV nucleoside reverse transcriptase inhibitors (NRTI) can cause peripheral neuropathy that is a result of mitochondrial injury. Polymorphisms in the mitochondrial genome define haplogroups that may have functional implications. The objective of this study was to determine if NRTI-associated peripheral neuropathy is associated with European mitochondrial haplogroups. DESIGN: Case-control study of Adult...
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