Article

Mutations on a novel brain-specific isoform of PGC1α leads to extensive upregulation of neurotransmitter-related genes and sexually dimorphic motor deficits in mice

2020-09-18

Abstract excerpt

The peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC1α) is known as a transcriptional co-activator in peripheral tissues but its function in the brain remains poorly understood. Various brain-specific Pgc1α isoforms have been reported in mice and humans, including transcripts derived from a novel promoter about ∼580 Kb upstream from the reference gene. These isoforms incorporate repetiti...

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Literature Corpus work: 5a9c5d0f-3463-5f28-a117-13e13dd93ba2
DOI: 10.1101/2020.09.18.300418

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