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Article

Deletion of the transcriptional coactivator PGC1α in skeletal muscles is associated with reduced expression of genes related to oxidative muscle function.

Biochemical and biophysical research communications - 9 Dec 2016

Hatazawa Yukino, Minami Kimiko, Yoshimura Ryoji, Onishi Takumi, Manio Mark Christian, Inoue Kazuo, Sawada Naoki, Suzuki Osamu, Miura Shinji, Kamei Yasutomi

Abstract excerpt

The expression of the transcriptional coactivator PGC1α is increased in skeletal muscles during exercise. Previously, we showed that increased PGC1α leads to prolonged exercise performance (the duration for which running can be continued) and, at the same time, increases the expression of branched-chain amino acid (BCAA) metabolism-related enzymes and genes that are involved in supplying substrates for the TCA...

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Source

Identifiers

PMID: 27816452
DOI: 10.1016/j.bbrc.2016.10.133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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