Article
PGC-1α is a male-specific disease modifier of human and experimental amyotrophic lateral sclerosis.
Human molecular genetics - 1 Sept 2013
Eschbach Judith, Schwalenstöcker Birgit, Soyal Selma M, Bayer Hanna, Wiesner Diana, Akimoto Chizuru, Nilsson Ann-Charloth, Birve Anna, Meyer Thomas, Dupuis Luc, Danzer Karin M, Andersen Peter M, Witting Anke, Ludolph Albert C, Patsch Wolfgang, Weydt Patrick
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a devastating, adult-onset neurodegenerative disorder of the upper and lower motor systems. It leads to paresis, muscle wasting and inevitably to death, typically within 3-5 years. However, disease onset and survival vary considerably ranging in extreme cases from a few months to several decades. The genetic and environmental factors underlying this variability are of great...
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