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Article

A brain-specific pgc1α fusion transcript affects gene expression and behavioural outcomes in mice.

Life science alliance - 1 Dec 2021

Lozoya Oswaldo A, Xu Fuhua, Grenet Dagoberto, Wang Tianyuan, Stevanovic Korey D, Cushman Jesse D, Hagler Thomas B, Gruzdev Artiom, Jensen Patricia, Hernandez Bairon, Riadi Gonzalo, Moy Sheryl S, Santos Janine H, Woychik Richard P

Abstract excerpt

PGC1α is a transcriptional coactivator in peripheral tissues, but its function in the brain remains poorly understood. Various brain-specific Pgc1α isoforms have been reported in mice and humans, including two fusion transcripts (FTs) with non-coding repetitive sequences, but their function is unknown. The FTs initiate at a simple sequence repeat locus ∼570 Kb upstream from the reference promoter; one also...

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Identifiers

PMID: 34649938
DOI: 10.26508/lsa.202101122
PMCID: PMC8548212

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