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Article

Molecular and Neural Functions of Rai1, the Causal Gene for Smith-Magenis Syndrome.

Neuron - 19 Oct 2016

Huang Wei-Hsiang, Guenthner Casey J, Xu Jin, Nguyen Tiffany, Schwarz Lindsay A, Wilkinson Alex W, Gozani Or, Chang Howard Y, Shamloo Mehrdad, Luo Liqun

Abstract excerpt

Haploinsufficiency of Retinoic Acid Induced 1 (RAI1) causes Smith-Magenis syndrome (SMS), which is associated with diverse neurodevelopmental and behavioral symptoms as well as obesity. RAI1 encodes a nuclear protein but little is known about its molecular function or the cell types responsible for SMS symptoms. Using genetically engineered mice, we found that Rai1 preferentially occupies DNA regions near active...

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Identifiers

PMID: 27693255
DOI: 10.1016/j.neuron.2016.09.019
PMCID: PMC5098476

Genes

SMS
RAI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Molecular and Neural Functions of Rai1, the Causal Gene for Smith-Magenis Syndrome.PMID 27693255Read ↗

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<i>RAI1</i> safeguards fidelity and tempo of human neurodevelopmental gene expressionSemantic proximity Read ↗

Smith-Magenis syndrome protein RAI1 regulates body weight homeostasis through hypothalamic BDNF-producing neurons and neurotrophin downstream signallingSemantic proximity Read ↗

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