Article

Convergent and distributed effects of the schizophrenia-associated 3q29 deletion on the human neural transcriptome

2020-05-27

Abstract excerpt

The 3q29 deletion (3q29Del) confers >40-fold increased risk for schizophrenia. However, no single gene in this interval is definitively associated with disease, prompting the hypothesis that neuropsychiatric sequelae emerge upon loss of multiple functionally-connected genes. 3q29 genes are unevenly annotated and the impact of 3q29Del on the human neural transcriptome is unknown. To systematically formulate unbiase...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5a954866-ff2f-50ad-b1a2-6dc81ea061af
DOI: 10.1101/2020.05.25.111351

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Convergent and distributed effects of the schizophrenia-associated 3q29 deletion on the human neural transcriptomeDOI 10.1101/2020.05.25.111351Read

Convergent and distributed effects of the 3q29 deletion on the human neural transcriptome.Semantic proximity Read

Single-cell multi-cohort dissection of the schizophrenia transcriptomeSemantic proximity Read

Massively parallel functional dissection of schizophrenia-associated noncoding genetic variants.Semantic proximity Read

Gene Expression Elucidates Functional Impact of Polygenic Risk for SchizophreniaSemantic proximity Read

Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis.Semantic proximity Read

The genome-wide risk alleles for psychiatric disorders at 3p21.1 show convergent effects on mRNA expression, cognitive function, and mushroom dendritic spine.Semantic proximity Read

Cross-species transcriptomic analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletionSemantic proximity Read

Gene expression elucidates functional impact of polygenic risk for schizophrenia.Semantic proximity Read

A foundational neuronal protein network model unifying multimodal genetic, transcriptional, and proteomic perturbations in schizophreniaSemantic proximity Read

Transcriptome Analysis of Cortical Tissue Reveals Shared Sets of Down-Regulated Genes in Autism and SchizophreniaSemantic proximity Read

Study protocol for The Emory 3q29 Project: evaluation of neurodevelopmental, psychiatric, and medical symptoms in 3q29 deletion syndrome.Semantic proximity Read

Coexpression network architecture reveals the brain-wide and multiregional basis of disease susceptibility.Semantic proximity Read