Article
The genome-wide risk alleles for psychiatric disorders at 3p21.1 show convergent effects on mRNA expression, cognitive function, and mushroom dendritic spine.
Molecular psychiatry - 1 Jan 2020
Yang Zhihui, Zhou Danyang, Li Huijuan, Cai Xin, Liu Weipeng, Wang Lu, Chang Hong, Li Ming, Xiao Xiao
Abstract excerpt
Schizophrenia and bipolar disorder (BPD) are believed to share clinical features, etiological factors, and disease pathologies (such as impaired cognitive functions and dendritic spine pathology). Meanwhile, there is growing evidence of shared genetic risk between schizophrenia and BPD, despite that our knowledge of the functional risk variations and biological mechanisms is still limited. Here, we conduct...
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