Article

Control of mammalian brain ageing by the unfolded protein response transcription factor XBP1

2020-10-07

Abstract excerpt

Brain ageing is the main risk factor to develop dementia and neurodegenerative diseases, associated with a decay in the buffering capacity of the proteostasis network. We investigated the significance of the unfolded protein response (UPR), a major signaling pathway to cope with ER stress, to the functional deterioration of the brain during aging. Genetic disruption of the ER stress sensor IRE1α accelerated cognit...

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Identifiers and source

Literature Corpus work: 1bcb806b-f055-5a81-b217-c32a8b446977
DOI: 10.21203/rs.3.rs-83658/v1

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