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Exogenous Hsp70 delays senescence and improves cognitive function in aging mice

14 Dec 2015

Abstract excerpt

Molecular chaperone Heat Shock Protein 70 (Hsp70) plays an important protective role in various neurodegenerative disorders often associated with aging, but its activity and availability in neuronal tissue decrease with age. Here we explored the effects of intranasal administration of exogenous recombinant human Hsp70 (eHsp70) on lifespan and neurological parameters in middle-aged and old mice. Long-term...

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PMID: 26668376
DOI: 10.1073/pnas.1516131112

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