Article
ER Stress, CREB, and Memory: A Tangled Emerging Link in Disease
26 Nov 2018
Abstract excerpt
The brain undergoes several changes at structural, molecular, and cellular levels leading to alteration in its functions and these processes are primarily maintained by proteostasis in cells. However, an imbalance in proteostasis due to the abnormal accumulation of protein aggregates induces endoplasmic reticulum (ER) stress. This event, in turn, activate the unfolded protein response; however, in most...
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