Article

Enhanced Protein-Protein Interaction Discovery via AlphaFold-Multimer

2024-02-21

Abstract excerpt

Accurately mapping protein-protein interactions (PPIs) is critical for elucidating cellular functions and has significant implications for health and disease. Conventional experimental approaches, while foundational, often fall short in capturing direct, dynamic interactions, especially those with transient or small interfaces. Our study leverages AlphaFold-Multimer (AFM) to re-evaluate high-confidence PPI dataset...

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Literature Corpus work: 5a5650e9-1123-5681-a952-983f8eb3e206
DOI: 10.1101/2024.02.19.580970

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