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Article

Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion.

Nature cell biology - 1 Oct 2012

Fonseca Sonya G, Urano Fumihiko, Weir Gordon C, Gromada Jesper, Burcin Mark

Abstract excerpt

Endoplasmic reticulum (ER) stress causes pancreatic β-cell dysfunction and contributes to β-cell loss and the progression of type 2 diabetes. Wolfram syndrome 1 (WFS1) has been shown to be an important regulator of the ER stress signalling pathway; however, its role in β-cell function remains unclear. Here we provide evidence that WFS1 is essential for glucose- and glucagon-like peptide 1 (GLP-1)-stimulated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22983116
DOI: 10.1038/ncb2578
PMCID: PMC3589109

Genes

WFS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion.PMID 22983116Read ↗

WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells.Semantic proximity Read ↗

[Wolfram syndrome: clinical features, molecular genetics of WFS1 gene].Semantic proximity Read ↗

Anti-inflammatory effects of WFS1 in pancreatic β-cellsSemantic proximity Read ↗

Dominant ER Stress-Inducing WFS1 Mutations Underlie a Genetic Syndrome of Neonatal/Infancy-Onset Diabetes, Congenital Sensorineural Deafness, and Congenital Cataracts.Semantic proximity Read ↗

Novel WFS1 variants are associated with different diabetes phenotypesSemantic proximity Read ↗

WFS1-related isolated diabetes induced by a WFS1 missense mutation: focus on the isolated diabetes phenotype.Semantic proximity Read ↗

Increased insulin demand promotes while pioglitazone prevents pancreatic beta cell apoptosis in Wfs1 knockout mice.Semantic proximity Read ↗

Endoplasmic reticulum stress induces Wfs1 gene expression in pancreatic β-cells via transcriptional activationSemantic proximity Read ↗

Liraglutide treatment reverses unconventional cellular defects in induced pluripotent stem cell-derived β cells harboring a partially functional WFS1 variantSemantic proximity Read ↗

ISR inhibition reverses pancreatic β-cell failure in Wolfram syndrome modelsSemantic proximity Read ↗

Wolfram syndrome and WFS1 gene.Semantic proximity Read ↗

WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells.Semantic proximity Read ↗

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