Article

A reference map of the human proinsulin biosynthetic interaction network

2019-07-11

Abstract excerpt

The beta-cell protein synthetic machinery is dedicated to the production of insulin, which plays a critical role in organismal homeostasis. Insulin synthesis requires the proper folding and trafficking of its precursor, proinsulin, yet the precise network of proinsulin protein interactions in the secretory pathway remains poorly defined. In the present study we conducted unbiased profiling of the proinsulin intera...

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Literature Corpus work: 27fdd567-fd50-5df0-808c-a207713b1292
DOI: 10.1101/699132

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