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Ectopic expression of DNMT3L in human trophoblast stem cells restores features of the placental methylome

8 Jan 2025

Abstract excerpt

The placental DNA methylation landscape is unique, with widespread partially methylated domains (PMDs). The placental “methylome” is conserved across mammals, a shared feature of many cancers, and extensively studied for links with pregnancy complications. Human trophoblast stem cells (hTSCs) offer exciting potential for functional studies to better understand this epigenetic feature; however, whether the hTSC...

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PMID: 39788122
DOI: 10.1016/j.stem.2024.12.007

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