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Article

Decoding the Heterodimer Stability of Pro-Apoptotic Effectors via Multiscale Simulations: Mutational Insights Into Mitochondrial Signaling.

Chemphyschem : a European journal of chemical physics and physical chemistry - 14 Apr 2026

Pani Pratyush, Shree Anvesha, Rana Malay Kumar

Abstract excerpt

The BCL-2 protein family plays a central role in regulating mitochondrial apoptosis, with Bcl-2 antagonist killer 1 (BAK) and Bcl-2-associated X protein (BAX) acting as key effectors that oligomerize to disrupt the outer mitochondrial membrane. While the mechanisms behind their homo-oligomerization are well studied, much less is known about their heterodimer. In this work, we explored how specific point mutations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41945779
DOI: 10.1002/cphc.202500782

Genes

BAX

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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