Article

Towards In Situ Dynamics of DNA-bound Full-Length p53 Tetramer

2025-10-15

Abstract excerpt

p53 is the most important tumor suppressor in humans as well as the most frequently mutated gene found in human cancers with ~50% of all human tumors bearing p53 missense mutations that leave p53 inactive. Restoring the p53 activity proved to lead to tumor regression even in advanced tumors in mouse models - and thus, is among the most attractive potential strategies for novel cancer therapy. Full-length p53 (fl-p...

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Literature Corpus work: 93bfafda-d567-5d63-8c4c-a90d9b3c2cf6
DOI: 10.1101/2025.10.14.682466

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