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Article

Mutation in MCL1 predicted loop to helix structural transition stabilizes MCL1-Bax binding interaction favoring cancer cell survival.

Proteins - 1 Sept 2022

Deepak Shyl Eby-Nesar Stella-Glory, Malgija Beutline, Iniyan Appadurai Muthamil, Vincent Samuel Gnana Prakash

Abstract excerpt

Myeloid cell leukemia-1 (MCL1), an anti-apoptotic BCL-2 family protein plays a major role in the control of apoptosis as the regulator of mitochondrial permeability which is deregulated in various solid and hematological malignancies. Interaction of the executioner proteins Bak/Bax with anti-apoptotic MCL1 and its cellular composition determines the apoptotic or survival pathway. Mutations act at various levels...

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PMID: 35429048
DOI: 10.1002/prot.26347

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