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Article

Impact of lymphoma-linked Asn11Tyr point mutation on the interaction between Bcl-2 and a BH3 mimetic: Insights from molecular dynamics simulation.

Chemical biology & drug design - 1 Apr 2020

Singh Khushboo, Briggs James M

Abstract excerpt

Frequent mutations in the Bcl-2 anti-apoptotic protein are often implicated in diffuse large B-cell lymphoma (DLBCL), a disease profoundly resistant to drugs. Bcl-2-competitive inhibitors, "BH3 mimetics," activate apoptosis by interfering with the interactions between pro-apoptotic BH3 domains and the hydrophobic groove of Bcl-2. The aim of our research is to determine the potential of DLBCL-linked N11Y mutation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32030875
DOI: 10.1111/cbdd.13653

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